Does Vitamin B12 Increase the Risk of Mortality

Vitamin B12 is a hydrosoluble vitamin that plays a significant role in 1-carbon metabolism. In addition to fetal development, the 1-carbon pathway has several biological functions, such as mitochondrial metabolism, immune response, and nucleotide homeostasis in nonproliferative tissues.

Vitamin B12 is an essential nutrient, useful in maintaining healthy nerves and blood, and can be found in foods such as sardines and eggs. If Vitamin B12 is found in high levels in a person’s blood is associated with an increased risk of early death. In the Netherlands, a study was carried out for their B12 levels with generally healthy men and women with an average age of 54 years. They were not taking any supplements. They tracked them for an eight-year average. Let’s further know how the research was carried out and what it results.

Additional health concerns

Researchers have found that in previous years those who were more likely to die of Vitamin B12 plasma concentrations also had other health issues such as they had high blood pressure, a higher concentration of glucose and cholesterol, their BMI index was high, higher urinary albumin excretion rates and more. This stated that people who had higher Vitamin B12 concentrates also had other health issues. 

B12 Supplementation

People who were given higher supplements of Vitamin B12 were also taken into the study and noticed some unusual results. Studies showed that when people were augmented by B12, there was no increased risk. 

High levels, B12 Triggered by ongoing condition

It emerged at the end of this study that increased levels of B12 can indicate damage to the liver or chronic kidney disease, indicating an impact of ongoing disease rather than a cause. To be specific the high levels of B12 were caused as the bodies were not able to efficiently absorb B12 due to liver or kidney disease, not because of the high intake of Vitamin B12. In other studies, also it was found that concentrations of vitamin B12 were observed in patients with tumors, liver, kidney, autoimmune, and infectious diseases. In addition, increased hepatocyte (liver cell) turnover or damage can lead to increased vitamin B12 leakage stored in the liver, resulting in higher blood concentrations of vitamin B12

Conclusion

This study states that Vitamin B12 is falsely blamed for Increasing the risk of mortality. This gets more support with the fact that high doses of vitamin B12 from diet or supplements in healthy people have not been associated with any harmful or adverse effects.

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