Soft gelatin capsules also referred to as softgels or soft elastic capsules, are one-piece, hermetically sealed capsules filled with a liquid or a semisolid substance, without air or gas bubbles. They are made from a gelatin film that is more flexible and has been plasticized with glycerin, sorbitol, or a related polyol.
Some can be created and manufactured to create a variety of different drug delivery systems, such as
- Chewable softgels with a highly flavorful shell that releases a liquid fill matrix when chewed.
- Suckable softgels made of a liquid matrix and a gelatin shell containing the flavoring to be squeezed.
- Twist-off softgels, which feature a tag that can be twisted or cut off to provide access to the fill material,
- Meltable softgels are intended to be used as suppositories or pessaries.
Since they allow the administration of liquids in a solid dosage form with a bioavailability advantage over other frequently used solid dosage forms, soft gel capsules have gained popularity in recent years. They come in a range of shapes, sizes, and colors that may be unique to the manufacturer. Read the article to know more about softgel capsules.
We are going to cover the following points in today’s article,
- Advantages and disadvantages of softgel capsules
- The manufacturing process of softgel capsule
- softgel capsule contract manufacturing Services
1. Advantages and disadvantages of softgel capsules
Advantages of soft gelatin capsules
- Many different colors, shapes, and sizes.
- No taste, unit dose delivery, and tamper-proof, easy to swallow.
- Allows a wide range of compounds to be filled in semi-solid, liquid, gel, or paste form.
- Can be used to deliver medication in a solution or other absorption-enhancing medium to increase bioavailability.
- Gelatin capsules digest quickly and dissolve in the stomach in a matter of minutes.
Disadvantages of soft gelatin capsules
- Need specialized manufacturing equipment.
- A small selection of gelatin-compatible excipients and carriers.
- Concerns with highly water soluble compounds’ stability
Using one of the following methods, softgels are manufactured,
- Plate process
- Accogel process
- Seamless process
- Reciprocating die process
- Rotary die process
The availability of the equipment and the volume of production required will determine which soft gelatin capsule manufacturing process is chosen.
As of now, the most popular methods for manufacturing Softgel capsules are the plate and rotary die processes.
2. The manufacturing process of soft gelatin capsules
The manufacturing process for softgel capsules is yet another crucial step in the capsule filling process. It is a simple process with 4 important steps. To guarantee that the final product meets high standards, there are a number of steps that you must correctly complete at every stage.
Let’s quickly understand each step in the manufacturing process for softgel capsules,
- Gelatin preparation
- Get the fill material ready
- Initiate the encapsulation procedure.
- Filled soft gelatin capsules are processed further.
1. Gelatin preparation
This typically serves as the “container” for the ingredients of softgel capsules. For this reason, the materials you select for the capsules’ outer shell should be of the finest quality. Additionally, it will shield the capsule’s contents from the effects of the outside environment. This would include matters like acidity, fluctuating heat or temperature, and humidity or moisture.
2. Get the fill material ready
This is the substance that you plan to combine with the gelatin. The fill material for Softgel may take one of the following forms during the manufacturing of softgel capsules:
- Semi-solid solution
- Suspension
- Liquid
Making sure the fill material is homogeneous throughout preparation is crucial. This will guarantee that each soft gelatin capsule contains all the essential ingredients.
3. Initiate the encapsulation procedure.
It is important to note that you must pick the right encapsulation machine before we even get into how this process works. The fill substance and gelatin shell should ideally combine to form capsules during the encapsulation stage.
4. Filled softgel capsules are processed further.
This stage of the manufacturing of soft gelatin capsules is also crucial. It typically involves the following crucial processes,
- Quality control in the soft gelatin capsules manufacturing process
- Drying soft gelatin capsules
- Polishing & packaging of soft gelatin capsules
As you can see, it is quite obvious that the manufacturing process for softgel capsules is simple and straightforward. All you require is the best Softgel encapsulation machine.
3. Soft Gel Capsule Contract Manufacturing
Nowadays, there are many contract manufacturing services available for soft gelatin capsules in the market. Contract manufacturing services have their own advantages and disadvantages.
If you are into Soft Gel Capsule Contract Manufacturing, Nutrapak is for you. Visit the website and get information about how they take their orders from contract manufacturers of various industries.
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